Full - Drug report, Montelukast, Asthma Treatment. structure function, metabolism, excretion.

Introduction Asthma is a common upset associated with the respiratory system; it affects peerless in four primary check children, one in seven teenagers, and one in ex adults in Australia (Bryant et al, 2002). thither argon many mediators involved in the pathogenesis of an asthma attack attack attack, and the tartness of the symptoms can digress between individuals. There ar several(prenominal) drugs that have been developed to dispense the overthrow, with differing mechanisms of action such as sympathomimetics, corticosteroids, leukotriene sensory receptor antagonists and mast-cell stabilizers. This case deals with the leukotriene receptor antagonist montelukast. Montelukast has been shown to be peculiarly effective in treating children with two mild persistent asthma and frequent episodic asthma (Knorr et al, 2001; Nat. Asthma Council, 2002), and individuals with aspirin-sensitive asthma (Seale, 1999). It is prone orally as the sodium salt of this compound (Singula ir ware Information, 2003), the structural formula is shown at a lower place Pathophysiology of Asthma As already stated, asthma is a disorder of the respiratory system, it occurs when the passage in and out becomes obstructed due to reversible bronchoconstricition, chronic inflammation of the epithelium of the airways, and increased mucous secretion (Bryant et al, 2002). There are many factors involved in the pathogenesis of asthma; such as leukotrienes, histamine, prostaglandins and other cytokines.

There are two main types of asthma; extrinsic (atopic, allergic) and intrinsic. Extrinsic asthma is trigger ed by substances that are not normally found! in the body such as allergens like pollen, dust mites and animate creature fur. Intrinsic is Mechanism of Action of Montelukast Put simply, montelukast is a reversible, competitive antagonist of leukotrienes selective for the CysLT1 receptor. The leukotrienes are products of arachidonic acid metabolism by 5-lipoxygenase (Borgeat et al, 1976), as shown in figure 1; on that point are 5 leukotrienes: LTA4, LTB4, LTC4, LTD4 and LTE4, of which the... If you requirement to get a adept essay, order it on our website: OrderCustomPaper.com

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